Uncoupling of mRNA synthesis and degradation impairs adaptation to host temperature in Cryptococcus neoformans
ALM Bloom, JTG Solomons, VE Havel… - Molecular …, 2013 - Wiley Online Library
The pathogenic fungus C ryptococcus neoformans must overcome multiple stressors to
cause disease in its human host. In this study, we report that C. neoformans rapidly and
transiently repressed ribosomal protein (RP) transcripts during a transition from 30° C to host
temperature. This repression was accompanied by accelerated mRNA degradation
mediated by the major deadenylase, Ccr 4, and influenced by the dissociable RNA
polymerase II subunit, Rpb 4. Destabilization and deadenylation of RP transcripts were …
cause disease in its human host. In this study, we report that C. neoformans rapidly and
transiently repressed ribosomal protein (RP) transcripts during a transition from 30° C to host
temperature. This repression was accompanied by accelerated mRNA degradation
mediated by the major deadenylase, Ccr 4, and influenced by the dissociable RNA
polymerase II subunit, Rpb 4. Destabilization and deadenylation of RP transcripts were …
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